The Garmin Express software gives you the option to continuously run Garmin Express in the task bar. If you disable the option, Garmin Express still continuously runs in Windows, though it does not show up in the taskbar. There is no reason anyone would need to continuously run their GPS software on a desktop. You can remove the entry using regedit to prevent it from starting automatically, but as soon as you run Garmin Express, again, it reinstalls the registry entry to auto-start when Windows starts.
In addition to this poor software design, the Garmin itself is only useful for major highways, and even then, I have often been taken down the rosy path regardless of the configurations I've tried. Also, any time I try to use their device to find a specific place, it is usually off by 10 miles. When attempting to navigate to a variety of existing commercial businesses, I have been taken to private residences, cemeteries (seems to be very often), various driving loops, and middle-of-nowhere roads-- i.e. "Turn Right in 100 ft"; "Hmm, that's a lake."
After several uses, my first Garmin Nuvi died. They were kind enough to replace it since it was within warranty, but I've quit using it. I've actually saved a lot of time by simply using my phone or my AAA US maps. I don't know if other GPS companies are as unscrupulous as Garmin, but they likely are. USB devices are a great way to get access to much of your personal information so that companies can sell your information to advertising conglomerates with no regard for your rights to privacy.